Methylation

Understand Your DNA. Optimize Your Biology.

Discover how methylation and nutrigenomics work together to power every cell in your body, and how understanding your genes can unlock energy, focus, and longevity.
Core Science

What is Methylation?

Methylation is one of your body’s most vital biochemical processes, occurring billions of times per second in every cell. It controls how your DNA is expressed, how your body produces energy, balances mood, detoxifies, and repairs itself.

Each "methylation” reaction transfers a methyl group (CH₃) to DNA, proteins, or hormones, turning certain genes on or off and keeping every system running efficiently.

When your methylation cycle runs smoothly, your body thrives. When it slows down due to genetic variations (SNPs), you may experience fatigue, inflammation, poor detoxification, or mood imbalances.

Core Science

What is Nutrigenomics?

Nutrigenomics is the science that studies how nutrients interact with your genes, influencing everything from metabolism and detoxification to mood and longevity.

It bridges the gap between your DNA and your daily choices, revealing how specific vitamins, minerals, and nutrients can turn your genes "on” or “off.”

This is the foundation of The Ultimate Human Wellness approach: Personalized science for real-world results.

Methylation Genes

The 13 genes that define your methylation pathway

At The Ultimate Human Wellness, our methylation report analyzes 13 key genes that form the foundation of your body’s most vital biochemical pathway – the methylation cycle. These genes directly influence DNA regulation, detoxification, neurotransmitter balance, hormone metabolism, and cellular energy.

Methylation is the body’s master regulatory process, turning genes on and off, producing neurotransmitters, repairing DNA, and supporting every cell. When this cycle slows, often due to genetic variations, it can affect mood, energy, detoxification, and longevity.

The 13 genes tested represent the critical control points of this process, determining how efficiently your body produces and recycles methyl groups, the chemical spark driving billions of reactions every second.

When functioning optimally, this network supports everything from brain chemistry and liver detox to cardiovascular and immune health. Even small inefficiencies can impact how your body performs, recovers, and ages.

Testing these genes reveals the blueprint of your methylation efficiency and provides a precise, actionable roadmap for optimizing the process that drives life itself.

Gene
Function
Why It’s Tested / Health Impact
MTHFR
Converts folate (B9) into active 5-MTHF
Inefficiencies can elevate homocysteine and slow detox & DNA repair
MTR
Regenerates methionine from homocysteine using B12
Key for SAM-e production and methylation continuity
MTRR
Regenerates active B12 for MTR function
Supports neurotransmitter balance and red blood cell production
BHMT
Provides “shortcut” methylation via betaine (TMG)
Supports liver detox & homocysteine balance
SHMT
Converts serine to glycine for one-carbon metabolism
Critical for DNA synthesis and methyl donor supply
AHCY
Converts SAH to homocysteine to keep methylation moving
Bottlenecks reduce detox, mood regulation, energy
ACAT
Links energy metabolism with methylation via acetyl-CoA
Impacts mitochondrial function and endurance
CBS
Directs homocysteine into the glutathione pathway
Regulates detox and antioxidant defense
MTHFD1
Generates folate derivatives for DNA repair
Influences fertility, energy, and cellular recovery
COMT
Breaks down dopamine, norepinephrine, estrogen
Affects stress response, focus, and hormonal balance
MAO-A
Metabolizes serotonin and dopamine
Influences mood, cognition, and emotional resilience
NOS3
Produces nitric oxide for vascular health
Impacts blood flow, oxygen delivery, and endurance
VDR
Regulates vitamin D activity and immune balance
Essential for calcium metabolism and mood
Your Genetic Advantage
Why it matters

Knowledge is the most powerful supplement you can take. Understanding how your genes influence methylation and nutrient function empowers you to make smarter, science-backed choices that enhance energy, focus, mood, and longevity. It’s not about changing your genes, it’s about understanding them so you can optimize your biology and unlock your highest potential.

Start your DNA journey