Disclaimer: This test does not include all possible risk variants for the COMT gene. Please talk to a healthcare professional if you think you might have symptoms associated with these variants, or you have any concerns about your results. You may wish to speak with a genetic counselor, board-certified clinical molecular geneticist, or equivalent health care professional about the results of your test. You can find information about doing so here: https://findageneticcounselor.nsgc.org/?reload=timezone The presence of these risk variants may not directly affect your day-to-day life. Some effects are too minuscule to notice and may not significantly impact your quality of life.
This product contains some of your top suggested ingredients based on the following traits:
• COMT
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Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Studyhttps://doi.org/10.1161/circgenetics.108.829804
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease, van Meurs et al., 2013. https://doi.org/10.3945/ajcn.112.044545
Exome-Wide Association Study Identifies East Asian-Specific Missense Variant MTHFR C136T Influencing Homocysteine Levels in Chinese Populations RH: ExWAS of tHCY in a Chinese Populationhttps://doi.org/10.3389/fgene.2021.717621
GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer, Christakoudi et al., 2021. https://doi.org/10.1038/s41598-021-89176-6
Molecular Biology of Methylenetetrahydrofolate Reductase (MTHFR) and Overview of Mutations/Polymorphisms, Leclerc et al., 2000-13. https://www.ncbi.nlm.nih.gov/books/NBK6561/
5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review, Botto et al., 2000. https://doi.org/10.1093/oxfordjournals.aje.a010290
Methylenetetrahydrofolate reductase and psychiatric diseases, Wan et al., 2018. https://doi.org/10.1038/s41398-018-0276-6
Association of the Maternal MTHFR C677T Polymorphism with Susceptibility to Neural Tube Defects in Offsprings: Evidence from 25 Case-Control Studies, Yan et al., 2012. https://doi.org/10.1371/journal.pone.0041689
MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis, Klerk et al., 2002. https://doi.org/10.1001/jama.288.16.2023
A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase, Frosst et al., 1995. https://doi.org/10.1038/ng0595-111
Disclaimer: Our reports and suggestions do not diagnose or treat any health conditions or provide any medical advice. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results.
