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How to read your results

We make it easier to see how your traits are influenced by your DNA. Each trait is displayed with a color-coded circle that reflects the severity level of your result. In addition to color, each result includes a descriptive label – such as Normal, Neutral, or Risk Variant Detected – to help clarify what the result means. You’ll also see additional trait labels throughout your reports, designed to make results more intuitive. These include labels like GAIN, LOSS, SHORTER, LONGER, SUNTAN, SUNBURN, and others.

Green

Normal

No risk variants present

This is great! A green color signifies that you are likely within the desired range for this trait. For some traits, it could also mean a lower genetic risk or likelihood for the undesired trait to develop.

Yellow

Neutral

1 risk variant present

If you see a yellow color, you are within the standard range or you may have a moderate likelihood or this trait. There may be some lifestyle changes to consider for optimizing your wellness.

Red

Risk Variant Detected

2 risk variants present

This color indicates a likely level of imbalance for this trait or a higher likelihood for it to develop. It is beneficial to consider supplementation and/or lifestyle changes, as well as consulting your healthcare provider.

MTHFR

Methylenetetrahydrofolate Reductase

About MTHFR

The MTHFR gene is responsible for providing instructions for making methylenetetrahydrofolate reductase enzyme, which helps the body process folate (Vitamin B9). Folate is needed for healthy red blood cell formation and is crucial during pregnancy for fetal development. MTHFR is involved in the process of converting homocysteine to methionine that the body can use for building proteins. MTHFR gene variants can cause elevated homocysteine levels. Homocysteine has been observed in studies to be toxic to cells and potentially be an indicator for cardiovascular problems when levels are elevated.

Risk Variant Present
_{2 risk variants present}

About your result

Based on your genetic profile, you may have reduced MTHFR enzyme activity.
_{Result based on:}_DNA

Disclaimer: This test does not include all possible risk variants for the MTHFR gene. Please talk to a healthcare professional if you think you might have symptoms associated with these variants, or you have any concerns about your results. You may wish to speak with a genetic counselor, board-certified clinical molecular geneticist, or equivalent health care professional about the results of your test. You can find information about doing so here: https://findageneticcounselor.nsgc.org/?reload=timezone The presence of these risk variants may not directly affect your day-to-day life. Some effects are too minuscule to notice and may not significantly impact your quality of life.

Individuals with MTHFR risk variant(s) may exhibit a decrease in normal enzyme activity. The enzyme activity could further decrease with the more risk variants carried.

People with risk variant(s) in this gene may have elevated levels of homocysteine in blood plasma compared to those without the risk variant. Increased homocysteine levels have been observed in studies to be toxic to cells and potentially be an indicator for cardiovascular problems.

People with MTHFR risk variants have been reported to be more susceptible to altered levels of DNA methylation compared to those without the risk variants.

Women who are pregnant or planning to become pregnant should speak to their physician or other healthcare provider about their MTHFR results, as processing folate properly is important for fetal development.

Interestingly, those with the risk variants may have a better working memory than those without the risk variants.

How to understand your gene analysis

Each GENE has a section that shows the specific SNPs looked at, your genotypes for those SNPs, and what those genotypes mean.

Calculating Your MTHFR Analysis

The most common variant of MTHFR is MTHFR C677T which affects up to 20% to 40% of the Caucasian and Hispanic population in the United States.

No risk variants present

1 risk variant present

2 risk variants present

Below, you'll see the SNP table that includes the gene being analyzed, the SNP(s) identified in peer-reviewed studies that can have an impact on the gene's function, and whether you have 0, 1, or 2 Risk Variants (also known as risk alleles) present in each SNP; these are represented by the letters A, C, T, and G. Having 0 Risk Variants is represented by a green circle, and generally means that you inherited 0 risk variants from your parents (Homozygous for non-risk variant). Having 1 Risk Variant is represented by a yellow circle, and generally means that you inherited a risk variant from one of your parents (Heterozygous). Having 2 Risk Variants is represented by a red circle, and generally means that you inherited a risk variant from each parent (Homozygous for risk variant). Please note that while most risk variants are inherited from parents, rare spontaneous mutations can also generate them.

Gene

MTHFR

Variation

C677T

A1298C

03/P39P

SNP

rs1801133

rs1801131

rs2066470

Genotype

Result

How to understand your trait analysis

Each trait report has a section that reveals the specific SNPs, genes, and genotypes we have looked into to determine your results. This section also shows how each gene affects your trait.

Calculating your Vitamin E Levels Analysis

Various genes, including CYP4F2, SCARB1, ZPR1, and their variants, affect the level and efficacy of vitamin E in the body. The level of vitamin E present in the body is associated with your immune response because it helps the immune system generate more antibodies in response to infection.

Gene

CYP4F2

SCARB1

ZPR1

SNP

rs2108622

rs11057830

rs964184

Genotype

Effect

The Science Behind Your Results

Your wellness is influenced by several factors, including your genetics, environment, and lifestyle.

Your results are based on up-to-date genetic research analyzed by The Ultimate Human Wellness's team of top research scientists. Periodically, our team revises traits to ensure they're fully up-to-date with the latest studies.

How are the results of my DNA traits determined?

Specific regions in your genetic makeup are called markers. Scientific studies have discovered that certain markers are linked to some unique traits such as your likelihood for gluten sensitivity or your body’s response to power and endurance exercises.

These markers are analyzed and utilized in order to show you how your DNA influences your wellness.

There are instances where we may be unable to determine a genetic variation in your DNA for various reasons. In these circumstances, we use a technique known as imputation to determine what it’s likely to be.

How Accurate Are Your Results?

Consider your genetic results as a peek inside your DNA instead of a guaranteed determination of your traits.

Your personal experience with certain traits depends on multiple factors, and our genetic makeup is an important part of that equation. Other factors include our environment, lifestyle, demographics, and other modifiers.

It is important to understand that one may have the genetic markers that predispose them to a condition, but still not develop it because their environmental factors may offset such risks.

If your DNA analysis suggests you have a higher likelihood of peanut allergy, but you can eat nuts safely, the markers we examined aren’t necessarily “wrong,” but they don’t reveal the complete story.

On the other hand, even if you have a low likelihood for a particular condition, it does not mean that you will never develop it.

It is also essential to understand that most traits are polygenic in nature, meaning multiple genes are responsible for their expression in our bodies.

So, impairment in one gene cannot contribute alone to your actual experience.

Some mechanisms may still try to offset or compensate for any errors in our bodies.

Genetics Glossary

Trait (Phenotype) - A trait is an obvious, observable, and measurable characteristic; it is the expression of genes in an observable way.

‍Gene - A gene is a portion of DNA that determines a certain trait.

‍SNP (single nucleotide polymorphism) - A SNP (pronounced “snip”) is the most common type of genetic variation among people

‍Genetic variation - A genetic variation is a difference in DNA sequences among individuals within a population.

‍Genotype - The genotype is the particular combination of alleles (inherited from parents) for a particular gene.

‍Allele - An allele is a specific form of a gene.

Understanding your results

How to read your results

Normal

Neutral

Risk Variant Detected

Inside your report

Depending on your results, there are certain diet, supplementation, and lifestyle changes that you need to consider in order to better manage your wellness.This section gives you personalized suggestions on how to manage your symptoms or reduce your risks for certain traits.

MTHFR

Methylenetetrahydrofolate Reductase

About MTHFR

Risk Variant Present
_{2 risk variants present}

About your result

Based on your genetic profile, you may have reduced MTHFR enzyme activity.
_{Result based on:}_DNA

Individuals with MTHFR risk variant(s) may exhibit a decrease in normal enzyme activity. The enzyme activity could further decrease with the more risk variants carried.

People with risk variant(s) in this gene may have elevated levels of homocysteine in blood plasma compared to those without the risk variant. Increased homocysteine levels have been observed in studies to be toxic to cells and potentially be an indicator for cardiovascular problems.

People with MTHFR risk variants have been reported to be more susceptible to altered levels of DNA methylation compared to those without the risk variants.

Women who are pregnant or planning to become pregnant should speak to their physician or other healthcare provider about their MTHFR results, as processing folate properly is important for fetal development.

Interestingly, those with the risk variants may have a better working memory than those without the risk variants.

How to understand your gene analysis

Each GENE has a section that shows the specific SNPs looked at, your genotypes for those SNPs, and what those genotypes mean.

Calculating Your MTHFR Analysis

The most common variant of MTHFR is MTHFR C677T which affects up to 20% to 40% of the Caucasian and Hispanic population in the United States.

How to understand your trait analysis

Each trait report has a section that reveals the specific SNPs, genes, and genotypes we have looked into to determine your results. This section also shows how each gene affects your trait.

Calculating your Vitamin E Levels Analysis

Various genes, including CYP4F2, SCARB1, ZPR1, and their variants, affect the level and efficacy of vitamin E in the body. The level of vitamin E present in the body is associated with your immune response because it helps the immune system generate more antibodies in response to infection.

Understanding your results

How to read your results

Normal

Neutral

Risk Variant Detected

Inside your report

Depending on your results, there are certain diet, supplementation, and lifestyle changes that you need to consider in order to better manage your wellness.This section gives you personalized suggestions on how to manage your symptoms or reduce your risks for certain traits.

MTHFR

Methylenetetrahydrofolate Reductase

About MTHFR

Risk Variant Present2 risk variants present

About your result

Based on your genetic profile, you may have reduced MTHFR enzyme activity.Result based on: DNA

Individuals with MTHFR risk variant(s) may exhibit a decrease in normal enzyme activity. The enzyme activity could further decrease with the more risk variants carried.

People with risk variant(s) in this gene may have elevated levels of homocysteine in blood plasma compared to those without the risk variant. Increased homocysteine levels have been observed in studies to be toxic to cells and potentially be an indicator for cardiovascular problems.

People with MTHFR risk variants have been reported to be more susceptible to altered levels of DNA methylation compared to those without the risk variants.

Women who are pregnant or planning to become pregnant should speak to their physician or other healthcare provider about their MTHFR results, as processing folate properly is important for fetal development.

Interestingly, those with the risk variants may have a better working memory than those without the risk variants.

How to understand your gene analysis

Each GENE has a section that shows the specific SNPs looked at, your genotypes for those SNPs, and what those genotypes mean.

Calculating Your MTHFR Analysis

The most common variant of MTHFR is MTHFR C677T which affects up to 20% to 40% of the Caucasian and Hispanic population in the United States.

How to understand your trait analysis

Each trait report has a section that reveals the specific SNPs, genes, and genotypes we have looked into to determine your results. This section also shows how each gene affects your trait.

Calculating your Vitamin E Levels Analysis

Various genes, including CYP4F2, SCARB1, ZPR1, and their variants, affect the level and efficacy of vitamin E in the body. The level of vitamin E present in the body is associated with your immune response because it helps the immune system generate more antibodies in response to infection.

Risk Variant Present
_{2 risk variants present}

Based on your genetic profile, you may have reduced MTHFR enzyme activity.
_{Result based on:}_DNA