Disclaimer: This test does not include all possible risk variants for the MTHFR gene. Please talk to a healthcare professional if you think you might have symptoms associated with these variants, or you have any concerns about your results. You may wish to speak with a genetic counselor, board-certified clinical molecular geneticist, or equivalent health care professional about the results of your test. You can find information about doing so here: https://findageneticcounselor.nsgc.org/?reload=timezone The presence of these risk variants may not directly affect your day-to-day life. Some effects are too minuscule to notice and may not significantly impact your quality of life.
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Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Studyhttps://doi.org/10.1161/circgenetics.108.829804
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease, van Meurs et al., 2013. https://doi.org/10.3945/ajcn.112.044545
Exome-Wide Association Study Identifies East Asian-Specific Missense Variant MTHFR C136T Influencing Homocysteine Levels in Chinese Populations RH: ExWAS of tHCY in a Chinese Populationhttps://doi.org/10.3389/fgene.2021.717621
GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer, Christakoudi et al., 2021. https://doi.org/10.1038/s41598-021-89176-6
Molecular Biology of Methylenetetrahydrofolate Reductase (MTHFR) and Overview of Mutations/Polymorphisms, Leclerc et al., 2000-13. https://www.ncbi.nlm.nih.gov/books/NBK6561/
5,10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review, Botto et al., 2000. https://doi.org/10.1093/oxfordjournals.aje.a010290
Methylenetetrahydrofolate reductase and psychiatric diseases, Wan et al., 2018. https://doi.org/10.1038/s41398-018-0276-6
Association of the Maternal MTHFR C677T Polymorphism with Susceptibility to Neural Tube Defects in Offsprings: Evidence from 25 Case-Control Studies, Yan et al., 2012. https://doi.org/10.1371/journal.pone.0041689
MTHFR 677C-->T polymorphism and risk of coronary heart disease: a meta-analysis, Klerk et al., 2002. https://doi.org/10.1001/jama.288.16.2023
A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase, Frosst et al., 1995. https://doi.org/10.1038/ng0595-111
Disclaimer: Our reports and suggestions do not diagnose or treat any health conditions or provide any medical advice. Consult with a healthcare professional before making any major lifestyle changes or if you have any other concerns about your results.
