Donates methyl groups straight through the BHMT enzyme, rather than working indirectly through the folate and B12 cycle like most methyl-donor supplements.
Because it bypasses that cycle, TMG still works when MTHFR, MTR, or MTRR variants slow the primary pathway, or when stress and high protein intake overwhelm it.
Betaine Anhydrous is the methyl-donor form, not Betaine HCl, which is a digestive-acid support with no methylation function.
Clean, Pure, and Potent. Produced in FDA-registered, GMP-certified facilities. Every batch is third-party tested for identity, purity, potency, heavy metals, microbial contamination, allergens, and stability. NON-GMO. Free from gluten, soy, dairy, unnecessary fillers, and artificial additives.
Our premium formulations are grounded in rigorous scientific research, ensuring that each ingredient is not only effective but also safe.
Why we chose it: Betaine Anhydrous is categorically different from Betaine HCl. Betaine HCl is primarily a digestive acid support supplement. Betaine Anhydrous (TMG) is the methyl-donor form, the version with established evidence for supporting healthy homocysteine levels and liver health. Provided in its pure anhydrous form for optimal absorption and direct activity.
What it supports: Donates methyl groups to support healthy homocysteine metabolism through an independent pathway that does not rely on B12 or folate. Supports liver health and healthy fat metabolism in the liver. Functions as a cellular osmolyte, protecting cells from heat and osmotic stress, which is relevant for athletes and active individuals. Supports energy and focus via its role in cellular methylation and SAMe production.[1][2][3][4]
Why we chose it: Flow agent used during manufacturing for consistent tablet production and enteric coating stability. Chosen as an alternative to chemical-laden binders.
What it supports: At the trace amount used, silica supports manufacturing consistency and has no meaningful physiological impact in this context.
TMG is a direct methyl donor — it doesn't rely on the folate and B12 cycle the way most methylation support does.
TMG gives up a methyl group through the BHMT enzyme, supporting healthy homocysteine metabolism and your body's own SAMe production.
Because it bypasses that cycle, TMG offers a parallel path that doesn't depend on those enzymes working optimally — relevant for people with MTHFR, MTR, or MTRR variants.
When the primary cycle is overwhelmed by stress or high protein intake, TMG supplies methylation capacity through a different door.
Peer-reviewed scientific research supporting the ingredients in our formulas at clinically meaningful doses. Each reference is provided for further review.
[1] Betaine Anhydrous
Craig SA. Betaine in human nutrition: BHMT pathway, methyl donation, homocysteine, fatty liver, vascular function. Am J Clin Nutr. 2004;80(3):539-549. PMID 15321791.
[2] Betaine Anhydrous
Arumugam MK, et al. Betaine as a systemic methyl donor and osmolyte: SAM:SAH ratio, liver, and metabolic health. Biology. 2021;10(6):456. PMID 34067313.
[3] Betaine Anhydrous
Olthof MR, et al. Dietary betaine lowers plasma homocysteine in healthy adults. J Nutr. 2003;133(12):4135-4138. PMID 14652361.
[4] Betaine Anhydrous
Ganguly P, Alam SF. Homocysteine, oxidative stress, endothelial damage, and cardiovascular disease risk. Nutr J. 2015;14:6. PMID 25577237.
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Important Notice: Food supplements should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. Do not exceed the recommended daily intake. If you are pregnant, breastfeeding, taking medication, or under medical supervision, consult your healthcare provider before use. Keep out of reach of children.
