D3 raises circulating calcium, but on its own it doesn't tell that calcium where to go.
K2 activates osteocalcin (calcium into bone) and Matrix Gla Protein (calcium out of arteries), the step most D3 supplements skip.
We use MK-7, with a ~72-hour half-life versus ~4 hours for MK-4, so one daily dose stays active all day and night.
Clean, Pure, and Potent. Produced in FDA-registered, GMP-certified facilities. Every batch is third-party tested for identity, purity, potency, heavy metals, microbial contamination, allergens, and stability. NON-GMO. Free from gluten, soy, dairy, unnecessary fillers, and artificial additives.
Our premium formulations are grounded in rigorous scientific research, ensuring that each ingredient is not only effective but also safe.
Why we chose it: Flow agent used during manufacturing for consistent tablet production and enteric coating stability. Chosen as an alternative to chemical-laden binders.
What it supports: At the trace amount used, silica supports manufacturing consistency and has no meaningful physiological impact in this context.
Why we chose it: Cholecalciferol is the form naturally produced by the skin in sunlight and is significantly more effective than D2 at raising and maintaining healthy Vitamin D levels. Research shows D3 raises serum 25(OH)D about twice as effectively as D2. At 100 mcg (4,000 IU), it delivers an optimal daily dose, not just enough to prevent deficiency.
What it supports: Supports strong bones, healthy calcium absorption, immune function, and healthy inflammatory balance. Supports mood and mental wellbeing through Vitamin D receptors found throughout the brain. Also helps regulate hundreds of genes involved in immune function, cellular repair, and hormone balance.[1][2]
Why we chose it: MK-7 is the superior form of vitamin K2, with a biological half-life of approximately 72 hours versus just 4 hours for MK-4. This provides consistent activity with once-daily dosing. K2 complements D3 by activating the proteins that direct calcium into bones and help prevent calcium buildup in arteries.
What it supports: Activates osteocalcin to bind calcium into bone for strength and density. Activates Matrix Gla Protein (MGP), which helps prevent calcium from depositing in arterial walls. Works with D3 to help ensure absorbed calcium ends up in the right place.[3][4]
D3+K2 isn't a methyl donor: its methylation-adjacent role is gene regulation and directing where minerals go.
D3 binds VDR to help regulate hundreds of genes; people with VDR variants may have reduced receptor sensitivity and benefit from consistent, adequate levels.
K2 (MK-7) activates osteocalcin and Matrix Gla Protein so absorbed calcium goes into bone, not arterial walls.
VDR signalling influences immune regulation and healthy inflammatory tone throughout the body.
Peer-reviewed scientific research supporting the ingredients in our formulas at clinically meaningful doses. Each reference is provided for further review.
[1] D3
Tripkovic L, et al. Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status. Am J Clin Nutr. 2012;95(6):1357-1364.
[2] D3
Hasific S, et al. Effects of vitamins K2 and D3 supplementation in patients with severe coronary artery calcification: a study protocol for a randomised controlled trial. BMJ Open. 2023;13(7):e073233.
[3] K2
van Ballegooijen AJ, et al. The synergistic interplay between vitamins D and K for bone and cardiovascular health. Int J Endocrinol. 2017;2017:7454376. PMID 29138634.
[4] K2
de Vries F, et al. Effects of one-year menaquinone-7 supplementation on vascular stiffness and blood pressure in post-menopausal women. Nutrients. 2025;17(5):815.
Every product in the Ultimate Human Wellness lineup is part of a broader, biology-first approach, helping you move from insight to action with clarity and purpose.
Important Notice: Food supplements should not be used as a substitute for a varied, balanced diet and a healthy lifestyle. Do not exceed the recommended daily intake. If you are pregnant, breastfeeding, taking medication, or under medical supervision, consult your healthcare provider before use. Keep out of reach of children.
