The active, bioavailable form of folate that bypasses the MTHFR conversion bottleneck entirely. Unlike folic acid — which requires conversion steps impaired in MTHFR variants — 5-MTHF is immediately usable regardless of genotype. Supports homocysteine recycling back to methionine and is the key methyl donor feeding SAMe production. Avoids the risk of unmetabolized folic acid accumulation associated with synthetic folic acid supplementation.
