The body's universal methyl donor and the downstream product of the full methylation cycle. SAMe drives over 200 methylation reactions including neurotransmitter synthesis and clearance (via COMT, PNMT, HNMT), DNA methylation (DNMT enzymes), Phase II hepatic detoxification, phospholipid synthesis, polyamine synthesis for cell repair, and joint proteoglycan and collagen synthesis. Enteric-coated tablet is essential — SAMe is acid-labile and degrades in gastric acid without enteric protection. Disulfate tosylate salt form is the most stable for oral delivery. Take on empty stomach for optimal absorption. Refrigerate after opening.
